The origin of most diseases appears mysterious. Consequently, treatments cannot be directed against the cause, but are only symptomatic or palliative. Treatment is often disappointing and many illnesses are considered as uncurable or incurable.
Why do the mechanisms remain unexplained?
Partly because most doctors and researchers are excessively specialized and they only consider a single facet of a pathological state, which in fact possesses many other aspects. A larger vision, using the date provided by all branches of medicine and biology, allows a much deeper analysis and results in a plausible conception of the physiopathology of different diseases.
Favouring hereditary factors, named susceptibility genes, are present but not sufficient. The intervention of environmental factor is necessary. In many cases most factors can be eliminated (radiation, chemical products, tobacco and other toxic substances, medication, allergens, viruses) and two suspects are retained : bacteria and food.
A great number of bacterial and alimentary macromolecules are able to penetrate the human organism and modern food is mainly responsible for this phenomenon.
Human enzymes and mucines are adapted to prehistoric food, but not to modern food which is very distant. The principal changes are the following :
* Consumption of animal milks and their derivativesWhy do the mechanisms remain unexplained?
Partly because most doctors and researchers are excessively specialized and they only consider a single facet of a pathological state, which in fact possesses many other aspects. A larger vision, using the date provided by all branches of medicine and biology, allows a much deeper analysis and results in a plausible conception of the physiopathology of different diseases.
Favouring hereditary factors, named susceptibility genes, are present but not sufficient. The intervention of environmental factor is necessary. In many cases most factors can be eliminated (radiation, chemical products, tobacco and other toxic substances, medication, allergens, viruses) and two suspects are retained : bacteria and food.
A great number of bacterial and alimentary macromolecules are able to penetrate the human organism and modern food is mainly responsible for this phenomenon.
Human enzymes and mucines are adapted to prehistoric food, but not to modern food which is very distant. The principal changes are the following :
* Ingestion of muted and cooked cereals
* Absorption of many over cooked products
* Utilisation of hot extracted vegetal oils
* Presence of numerous chemical additives
* Partial deficit for some minerals and vitamins
Modern food appears as the first cause of many unexplained diseases. It provokes three modifications in an essential organ, the small bowel :
1) Some aliments are incompletely degraded, for the digestive enzymes are not adapted to their structure. The consequence is an excess of alimentary macromolecules.
2) Gut flora is altered and turns into a putrefaction flora, with proliferation of some dangerous bacteria. The metabolism, the death or the destruction by an immune response of these bacteria release an excess of bacterial macromolecules.
3) This abnormal intestinal content is agressive towards the gut mucosa, which is fragile, because it is very extensive (100 square meters) and very thin (1/40 of millimeter). The gut barrier becomes too permeable.
Stresses aggravate the small bowel hyperpermeability, for they induce a gamma interferon secretion. This mediator binds to gut mucosa epithelial cells, leading to a spacing between these cells.
Later on, some bacterial and alimentary macromolecules arrive in blood circulation. The composition of these molecules varies according to individuals, for it is conditioned by variations in gut flora, alimentary habits and efficacy of enzymes which cut proteins, lipids and glucids at different sites. According to their structure, these molecules will have an affinity for various types of cells and tissues. They can provoke three categories of pathology :
1) The peptides are going to bind with HLA molecules, which present these peptides to T cells. These lymphocytes are unable to recognize a whole agressor : bacterium, virus ou protein. Their little membrane receptors only allow the recognition of relatively small peptides, and these peptides must be associated with HLA molecules. Activated T cells induce an immune response directed against the cells which express the peptide. The consequence will be an autoimmune disease :
* Rheumatoid arthritis (Proteus mirabilis peptide in synovial and chondral cells, coupled with HLA-DR4 or HLA-DR1).
* Ankylosing spondylitis (Klebsiella pneumoniae peptide in enthesis, coupled with HLA-B27).
* Grave's disease (Yersinia enterocolitica peptide in thyroid epithelial cells, coupled with HLA-DR3).
* Coeliac disease (gluten gliadine peptide in small bowel mucosa epithelial cells, coupled with HLA-DR53 ou HLA-DQ2) and so on ...
2) The non peptidic molecules essentially include bacterial ADN, bacterial lipopolysaccharides, products of Maillard's reaction, isomeres of proteins, lipids and glucids. These substances are poorly recognized or not recognized by lymphocytes and do not stimulate an immune response. But they may settle in extracellular medium, they may block some membrane receptors and they may accumulate in cytoplasm and nucleus of cells. The outcome is a "clutter" pathology :
* Maturity onset diabetes mellitus (cluttering of endocrine pancreas, muscles and adipose tissue)
* Fibromyalgia (cluttering of molecules, tenders and brain)
* Arthrosis (cluttering of chondral cells)
cancers (cluttering provoking some genetic alterations which transform a normal cell into a malignant cell) and so on ...
3) The human organism attempts to evaluate these nocious wastes. The macromolecules which are unbreakable by enzymes, remain whole. They must be carried by macrophages and neutrophils, escorted by lymphocytes, from blood circulation to the outside, through various tissues. The tissues infiltrated by leukocytes become inflammed and the chronic inflammation leads to the elimination pathology :
* Through the skin : acnea, psoriasis
* Through the colon : irritable bowel, Crohn's disease
* Through the bronchia : bronchitis, asthma
* Through the mucosa of ORL sphera : recurrent infections, hay fever, Behçet's disease and so on ...
The logical treatment of all quoted diseases is the return to an ancestral diet, close to that practiced by prehistoric men :
* Suppression of animal milks and their derivatives
* Suppression of cereals, except rice which has never muted
* Consumption of products, either crude, or cooked at a temperature lower than 110°C
* Use of oils obtained by first pression, at cold temperature
* Preference for biological aliments
* Supplementation with physiological quantities of minerals and vitamins.
In practice, this diet is very often and very intensely efficient. To show some examples, it considerably improves or leads to a complete remission :
1) Among autoimmune diseases :1) Some aliments are incompletely degraded, for the digestive enzymes are not adapted to their structure. The consequence is an excess of alimentary macromolecules.
2) Gut flora is altered and turns into a putrefaction flora, with proliferation of some dangerous bacteria. The metabolism, the death or the destruction by an immune response of these bacteria release an excess of bacterial macromolecules.
3) This abnormal intestinal content is agressive towards the gut mucosa, which is fragile, because it is very extensive (100 square meters) and very thin (1/40 of millimeter). The gut barrier becomes too permeable.
Stresses aggravate the small bowel hyperpermeability, for they induce a gamma interferon secretion. This mediator binds to gut mucosa epithelial cells, leading to a spacing between these cells.
Later on, some bacterial and alimentary macromolecules arrive in blood circulation. The composition of these molecules varies according to individuals, for it is conditioned by variations in gut flora, alimentary habits and efficacy of enzymes which cut proteins, lipids and glucids at different sites. According to their structure, these molecules will have an affinity for various types of cells and tissues. They can provoke three categories of pathology :
1) The peptides are going to bind with HLA molecules, which present these peptides to T cells. These lymphocytes are unable to recognize a whole agressor : bacterium, virus ou protein. Their little membrane receptors only allow the recognition of relatively small peptides, and these peptides must be associated with HLA molecules. Activated T cells induce an immune response directed against the cells which express the peptide. The consequence will be an autoimmune disease :
* Rheumatoid arthritis (Proteus mirabilis peptide in synovial and chondral cells, coupled with HLA-DR4 or HLA-DR1).
* Ankylosing spondylitis (Klebsiella pneumoniae peptide in enthesis, coupled with HLA-B27).
* Grave's disease (Yersinia enterocolitica peptide in thyroid epithelial cells, coupled with HLA-DR3).
* Coeliac disease (gluten gliadine peptide in small bowel mucosa epithelial cells, coupled with HLA-DR53 ou HLA-DQ2) and so on ...
2) The non peptidic molecules essentially include bacterial ADN, bacterial lipopolysaccharides, products of Maillard's reaction, isomeres of proteins, lipids and glucids. These substances are poorly recognized or not recognized by lymphocytes and do not stimulate an immune response. But they may settle in extracellular medium, they may block some membrane receptors and they may accumulate in cytoplasm and nucleus of cells. The outcome is a "clutter" pathology :
* Maturity onset diabetes mellitus (cluttering of endocrine pancreas, muscles and adipose tissue)
* Fibromyalgia (cluttering of molecules, tenders and brain)
* Arthrosis (cluttering of chondral cells)
cancers (cluttering provoking some genetic alterations which transform a normal cell into a malignant cell) and so on ...
3) The human organism attempts to evaluate these nocious wastes. The macromolecules which are unbreakable by enzymes, remain whole. They must be carried by macrophages and neutrophils, escorted by lymphocytes, from blood circulation to the outside, through various tissues. The tissues infiltrated by leukocytes become inflammed and the chronic inflammation leads to the elimination pathology :
* Through the skin : acnea, psoriasis
* Through the colon : irritable bowel, Crohn's disease
* Through the bronchia : bronchitis, asthma
* Through the mucosa of ORL sphera : recurrent infections, hay fever, Behçet's disease and so on ...
The logical treatment of all quoted diseases is the return to an ancestral diet, close to that practiced by prehistoric men :
* Suppression of animal milks and their derivatives
* Suppression of cereals, except rice which has never muted
* Consumption of products, either crude, or cooked at a temperature lower than 110°C
* Use of oils obtained by first pression, at cold temperature
* Preference for biological aliments
* Supplementation with physiological quantities of minerals and vitamins.
In practice, this diet is very often and very intensely efficient. To show some examples, it considerably improves or leads to a complete remission :
* 80 % of patients in rheumatoid arthritis
* 95 % in ankylosing spondylitis
* 80 % in psoriatic rheumatism
* 70 % in Sjögren's syndrome
2) Among cluttering diseases :
* 75 % of patients in maturity onset diabetes mellitus
* 80 % in fibromyalgia
* 75 % in arthrosis
And an evident preventive effect on cancer (except skin tumors) : only one case occurred among 1000 subjects who practiced the ancestral diet since a mean of 5 years (the expected number was 18 cases).
3) Among elimination diseases :
* 99 % of patients in acnea
* 99 % in irritable bowel
* 97 % in Crohn's disease
* 90 % in asthma
* 99 % in hay fever
The hypotoxic diet often cures a disease, but cannot repair some definitive lesions : articular deformations in rheumatoid arthritis, destruction of lachrymal and salivary glands in Sjögren's disease, scars in acnea, stenosis, abcess, fistula or fissure in Crohn's disease, and so on... Chronic bronchitis is curable, but not bronchectasia, for the elastic tissue of bronchia is distented. Therefore, it is essential to start the nutritional change as soon as possible.
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